It would be interesting to determine if dopamine (a monoamine catecholamine compounds) in the environment affect bacterial social and motility behaviors. Understanding this interaction in P. aeruginosa species could provide new insights into the regulation of the virulence of this pathogen in both environmental and clinical settings. In this case report, we examined two clinical isolates of Pseudomonas aeruginosa for their ability to produce biofilm with a chemotaxis behavior for the dopamine to explain this social behavior.