Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing Highlights d Acetylcholine is released in the mouse barrel cortex during active whisker sensing d Acetylcholine depolarizes inhibitory cells expressing vasoactive intestinal peptide d Excitation of vasoactive intestinal peptide-expressing neurons causes disinhibition d Cholinergic-driven disinhibition could gate sensorimotor integration and plasticity
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