Background : The Thalassaemia is an inherited haemoglobulin disorder causes hemolytic anemia which usually requires life-long blood transfusion therapy. Therefore transfusion dependent thalassaemia major patients suffer from the effect of deposition of excess iron in the liver, heart and endocrine glands.Objective : The aim of present study was to find out the association of serum ferritin and SGPT in transfusion dependent thalassaemia major patient.Methodology : This cross sectional study was carried out in Day care unit (DCU) of Transfusion Medicine department, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, during January 2014 to December 2014. Total of 110 clinically diagnosed Thalassaemia major (TM) between (5-35 years) cases of either sex from the above mentioned department attending the DCU were selected purposively for this study. Data were collected on clinical examination findings, laboratory investigations, ABO and Rh Blood Group, Serum ferritin and SGPT (Serum glutamic pyruvic transaminase) after taking informed consent.Results : The following observations and results were obtained in this study. The mean age was found 17.15±8.77 years with range from 5 to 35 years and male to female ratio was 1.2:1 (male 59 and female 51). Sixty eight (68.0%) patients came from rural area, 43.6% patients were student, 77.3% patients had completed primary education, 57.3% of the patients came from middle class family and 72.7% patients were unmarried. About 46.4% of the patients had moderate anaemia, 28.2% had jaundice, 79.1% had hepatomegaly, 82.7% had splenomegaly and 30.9% had complication due to iron overload. Mean haemoglobulin (Hb%) was found 6.65±1.63 gm/dl, mean serum ferritin was found 3785±17637 ?g/L and mean SGPT was found 134.8±77.94 U/L. There was a significant positive correlation (r=0.259; p=0.006) between serum ferritin and SGPT.Conclusion : Considering the study result it can be concluded that there is a positive significant correlation between serum ferritin with SGPT level.Northern International Medical College Journal Vol.8(1) July 2016: 170-173

Background and Objectives: In 1939, D antigen was discovered which is believed to be the most immunogenic antigen in Rhesus (Rh) blood group system. There are some D variants such as weak D, partial D, and DEL due to gene polymorphism. These variants can cause RhD-positive person to behave like RhD negative which could result in alloimmunization. Clinically weak D antigen is very important due to its strong immunogenicity in spite of its low frequency. Hence, we need to know the prevalence of weak D variants in the community. The purpose of this study is to find out weak D prevalence among the Bangladeshi population. Methods: It is a retrospective study done over the last 5 years, from January 2015 to December 2019, at the department of transfusion medicine of three tertiary care hospitals in Bangladesh. A total of 177,702 patients were enrolled in the study. Blood samples that were negative for RhD were tested for weak D by indirect antiglobulin test according to institutional protocol. Results: Out of 177,702 patients, 7359 (4.1%) were found to be RhD negative and among those, 14 (0.19%) were weak D antigen positive. Conclusion: Weak D antigen is prevalent in Bangladesh and every RhD-negative individual should be checked for the presence of weak D to prevent RhD alloimmunization.

Background: Transfusion of blood components and derivatives in day care unit is an eminent part of management of transfusion dependent patients. Day care transfusion service is an alternative to hospital admission and beneficial for those patients who receive blood more frequently for their survival. Objective: The aim of present study is to assess Transfusion Services provided in a Day Care Unit (DCU) of a tertiary care hospital. Methodology: This study was carried out in DCU of Transfusion Medicine Department, Bangabandhu Sheikh Mujib Medical University, (BSMMU) at Dhaka during January 2014 to December 2014. Data were collected from record registers. Recorded retrospective data were analyzed as percentage and proportion. Results: Total recipients were 718. Among those 424 (59.05%) were male and 294 (40.95%) were female and 562 (78.27%) were between 10 to 40 years. A total of 8587 units of blood components were used during this period. Red Cell Concentrate was most commonly utilized product 6388 (74.39%) followed by Fresh Frozen Plasma (FFP) 1360 (15.83%), Platelet Concentrate 544 (6.33%), Whole blood 260 (3.05%) and Cryoprecipitate 35 (0.40%). Transfusion was required more frequently in thalassaemic 365(50.88%) patients. Haemophilia 77(10.72%) and aplastic anaemia patients 49 (6.82%) were next high. The main transfusion reaction observed during transfusion was febrile non-haemolytic reactions. Conclusion: For increasing use of specific blood product and hassle-free transfusion services this kind of day care unit services should be strengthened. Long term study of this kind will help us to develop safe clinical transfusion practice.

Transfusion of blood components and derivatives in day care unit is an eminent part of management of transfusion dependent patients. Day care transfusion service is an alternative to hospital admission and beneficial for those patients who receive blood more frequently for their survival. The aim of present study is to assess Transfusion Services provided in a Day Care Unit (DCU) of a tertiary care hospital. This study was carried out in DCU of Transfusion Medicine Department, Bangabandhu Sheikh Mujib Medical University, (BSMMU), in Dhaka during January to December 2014. Data were collected from record registers. Recorded retrospective data were analyzed as percentage and proportion. Total recipients were 718. Among those 424 (59.05%) were male and 294 (40.95%) were female and 562 (78.27%) were between 10 to 40 years. A total of 8587 units of blood components were used during this period. Red Cell Concentrate was most commonly utilized product 6388 (74.39%)  followed by FFP 1360 (15.83%), Platelet Concentrate 544 (6.33%), Whole blood 260 (3.05%) and Cryoprecipitate 35(0.40%). Transfusion was required more frequently in thalassaemic 365(50.88%) patients. Haemophilia 77(10.72%) and aplastic anaemia patients 49 (6.82%) were next high. The main transfusion reaction observed during transfusion was febrile non-haemolytic reactions. For increasing use of specific blood product and hassle free transfusion services this kind of day care unit services should be strengthened. Long term study of this kind will help us to develop safe clinical transfusion practice. Bangladesh Med J. 2019 May; 48 (2): 28-31