Aim:The aim of this study was to compare maternal blood and umbilical-cord leptin, spexin and visfatin levels during delivery in severe preeclampsia (PE) with controls, and to evaluate whether any clinical or demographic variables had independent associations with them. Methods: This is a case-controlled observational study consisting of 45 pregnant women with severe PE and a control group consisting of gestational age-matched 45 healthy pregnant women. We examined the leptin, spexin, and visfatin levels in serum samples taken from maternal blood and umbilical cords during cesarean section in both groups. Leptin, spexin, and visfatin levels were measured by enzyme-linked immunosorbent assay. Results: The maternal leptin and visfatin levels were significantly higher and the maternal spexin levels were significantly lower in the PE group than in the control group (p < 0.001). Similar to the maternal adipokine levels, the umbilical-cord leptin and visfatin levels were significantly higher and the spexin levels were significantly lower in the PE group (p < 0.001). We found a significant positive correlation between maternal body mass index and maternal blood and umbilical-cord serum leptin and visfatin levels in both groups (p < 0.001). Conclusion:The leptin, spexin and visfatin levels were significantly altered in the nondiabetic preeclamptic women in our study. We believe that the main reason for these changes may be the hypoxic placenta to protect the fetus and maintain its nutrition.

Background and Objectives: The goal of this study was to investigate the effect of selective serotonin reuptake inhibitor treatment on the ovarian reserves of women of reproductive age with major depressive disorder. Materials and Methods: The current study is a prospective controlled trial including 48 women with major depressive disorder and 48 age-matched healthy controls. Ovarian reserve tests are performed prior to treatment and after six cycles of selective serotonin reuptake inhibitor treatment in the major depressive disorder group. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, and anti-Müllerian hormone levels were evaluated from blood samples, and endometrial thickness, total antral follicle count, and volume of both ovaries were assessed using transvaginal ultrasonography. Results: When the first measurements were compared, menstrual duration and menstrual bleeding increased (p = 0.007 and 0.005, respectively) and luteinizing hormone decreased (p = 0.045) in the major depressive disorder group, while follicle-stimulating hormone, estradiol, anti-Müllerian hormone, endometrial thickness, total antral follicle count, and mean ovarian volume did not differ significantly between groups (p > 0.05). When the major depressive disorder group’s first and final measurements were compared, follicle-stimulating hormone, estradiol, and endometrial thickness increased (p = 0.05, 0.0001, and 0.005, respectively), luteinizing hormone remained constant (p = 0.541), and anti-Müllerian hormone and total antral follicle count decreased (p = 0.024 and 0.042, respectively). Conclusions: In this study, we observed that the ovarian reserve test results of patients diagnosed with major depression for the first time after 6 months of SSRI treatment were significantly different from the results of the pretreatment and control groups.

Objective: This study was conducted to evaluate the rates of postpartum depression by using Edinburgh Postpartum Depression Scale among mothers who visited our clinics 6-8 weeks after giving birth, and the effects of some sociodemographic and obstetrical factors on postpartum depression. Materials and methods: This cross-sectional study included 318 women who gave birth 6-8 weeks ago and visited obstetrical and gynecology or pediatrics clinics for routine control. Some sociodemographic and obstetrical data which were thought to be a potential risk factor for postpartum depression were recorded and Edinburgh postpartum Depression Scale was conducted for each patient. Results: 104 patients (32.7%) were diagnosed with postpartum depression. Postpartum depression rates were significantly higher in patients with low education levels and occupations of both mothers and their partners, depression history, dissatisfaction from marriage, smoking, increased number of parity and abortion, unplanned pregnancy, nausea and emesis during pregnancy, birth before 36 week pregnancy, increase in length of hospitalization, baby care in incubator, insufficient support and lack of breastfeeding. Conclusion: There is a significant relationship between some sociodemographic and obstetrical conditions and postpartum depression. Identification of the risk groups and early precautions can reduce the high prevalence of the disease during the pandemic.

Amaç: Vajinal duş, vajinal floraya ve ekosisteme zarar verir. Vajinal flora dengesinin bozulması, kadın ve yenidoğan sağlığı üzerinde olumsuz etki yapan birçok nedene yol açmaktadır.Materyal ve metod: Çalışmaya vajinal duş uygulayan 105 hasta dahil edildi. Tüm kadınlardan Pap smear testi alındı. Hastalara neden vajinal duş alışkanlıklarını bırakmaları gerektiğine dair yazılı bilgi verildi. 30 günden önce olmamak üzere ikinci bir Pap smear testi için randevu günü verildi. Hastaların ilk Pap smearleri alındıktan sonra hiçbirine enfeksiyon tedavisi verilmedi. Vajinal duştan önce ve sonra alınan pap smear sonuçları karşılaştırıldı.Bulgular: Pap smear sonuçlarının detaylı karşılaştırmasında şiddetli inflamasyonu olan hasta oranının %11,4'ten %1,9'a düştüğü görüldü. Şiddetli inflamasyondaki azalma istatistiksel olarak anlamlı bulundu (p=0,006). Hafif veya şiddetli ayrımına bakılmaksızın enfeksiyonlu hastalar karşılaştırıldığında; tipik enfeksiyon bulgusu olan olguların oranının %48,5'ten %31,4'e düştüğü görüldü ve istatistiksel olarak anlamlı bulundu (p=0,01).Sonuçlar: Vajinal flora; bir çok faktörün etkisi altında olan, çok karmaşık ve dinamik bir bileşendir. Vajinal duş, vajinal flora yapısına ve dengesine zarar verir. Basit bir vajinal enfeksiyondan servikal neoplaziye kadar geniş bir yelpazede kadın sağlığını olumsuz etkiler.