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The development of delirium can lead to severe and significant consequences for the patient. The primary aim of the study was to identify potential differences in clinical characteristics and medical management between elderly hospitalized patients with delirium and with and without coronavirus disease 2019 (COVID-19). A secondary aim was to report the short-term outcomes and possible predictors of outcomes of both patient groups. A retrospective study was conducted. Patients' records were screened for delirium. Clinical and laboratory data were collected, including baseline inflammatory markers. No significant difference was found between the patients with and the patients without COVID-19 regarding clinical characteristics and the dose of antipsychotic medication. COVID-19-positive delirium was not different from COVID-19-negative delirium in terms of length of hospital stay, intensive care, and antipsychotic needs. Monocyte to lymphocyte ratio (MLR) may be a predictor of survival in patients with COVID-19 and delirium. [ Psychiatr Ann. 2022;52(8):338–348.]

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