AA1050 Al alloy samples were shot-peened using stainless-steel shots at shot peening (SP) pressures of 0.1 and 0.5 MPa and surface cover rates of 100% and 1000% using a custom-designed SP system. The hardness of shot-peened samples was around twice that of unpeened samples. Hardness increased with peening pressure, whereas the higher cover rate did not lead to hardness improvement. Micro-crack formation and embedment of shots occurred by SP, while average surface roughness increased up to 9 µm at the higher peening pressure and cover rate, indicating surface deterioration. The areal coverage of the embedded shots ranged from 1% to 5% depending on the peening parameters, and the number and the mean size of the embedded shots increased at the higher SP pressure and cover rate. As evidenced and discussed through the surface and cross-sectional SEM images, the main deformation mechanisms during SP were schematically described as crater formation, folding, micro-crack formation, and material removal. Overall, shot-peened samples demonstrated improved mechanical properties, whereas sample surface integrity only deteriorated notably during SP at the higher pressure, suggesting that selecting optimal peening parameters is key to the safe use of SP. The implemented methodology can be used to modify similar soft alloys within confined compromises in surface features.

BackgroundFamilial Mediterranean Fever (FMF) is an autosomal recessive genetic disorder that causes recurrent episodes of fever, poliserositis, arthritis, skin eruptions.ObjectivesIn this study, we aim to present clinical and demographic features of FMF patients followed up in our clinic.MethodsThe clinical, demographic, genetic features and managements of 402 FMF patients (fulfilling Tel-Hashomer Diagnostic Criteria) were analysed.ResultsThe mean age was 36.8±11.2 years, mean diagnosis age was 28±11.9 years, and mean disease duration was 189.2±124.5 months, mean duration between onset of disease and onset of treatment was 93.6±104 months. Consanguineous marriage was detected in 7%29 patients. Fever and abdominal pain both were initial symptoms in 72% of the patients, while 7% of them had chest pain, 4% had only fever, 15% had arthritis, 1% had erysipel-like erythema and 1.5% had inflammatory back pain as the first symptom of FMF (table 1).Eight patients (2%) were suffered from chronic kidney disease and 2 of them were on dialysis programme. Amyloidosis were identified in 14 patients (3.5%) with biopsy.At least one mutation of MEFV gene was detected in 78% patients There was no mutation in 8% patients. In 15% patients, MEFV gene analysis could not be done. The most frequent mutation was M694V mutation and its allel frequency was 54%; the frequency of V726A, M680I, E148Q, R761H and A744S allels mutation were 11%, 7%, 7%, 2%, 1%, respectively. The frequency of compound mutation was 38%, and the most common compound mutation was M694V+R202Q (11%).There was significantly relationship between M694V mutation and arthritis, erysipel-like erythema, proteinuria, sacroiliitis(table 2). Amyloidosis was more frequent in patients who had M694 homozygous mutation. Mean age of disease onset was lower in patient who had M694V homozygous mutation than M694V heterozygous mutation (p<0.001).Abstract SAT0591 – Table 1Demografical and Clinical Features of FMF Patientsn=402n(%) Gender FemaleMale241 (60)161 (40)Fever299 (75.5)Abdominal Pain347 (86)Erysipel-like erythema54(13Chest pain83 (21)Positive family history174 (43)Appendectomy96(24Amyloidosis14 (3.5)Chronic kidney disease8 (2)İnflammatory back pain63(16Arthritis129 (32)Hip pain27 (7)Heel pain30 (7.5)Uveitis4 (1)Sacroiliitis44(11Biological treatment16(4Abstract SAT0591 – Table 2Relationship between M694V mutation and clinical findingsConclusionsTight control and sustained management are important in FMF to protection from amyloidosis. Similar to literature, the most frequent mutation was M694V mutation, and there was significantly relationship between M694V mutation and arthritis, erysipel-like erythema(1), proteinuria, sacroiliitis(2) in our study.References[1] Dewalle M, Domingo C, Rozenbaum M, et al. Phenotype-genotype correlation in Jewish patients suffering from familial Mediterranean fever (FMF). Eur J Hum Genet1998;6:95–7.[2] Akkoc N, Sari I, Akar S, et al. Increased prevalence of M694V in patients with ankylosing spondylitis: additional evidence for a link with Familial Me...