The incidence of thyroid cancer has been greatly increasing. Several studies aimed to investigate biomarkers for prediction of thyroid cancer. Some of these studies have suggested that thyroid autoantibodies (TAb) could be used as predictors of thyroid cancer risk, but the correlation between TAb and PTC is still a matter of debate. The aim of this study is to evaluate thyroid autoimmunity and TAbs in patients with PTC and benign multinodular goiter (MNG) to investigate if TAbs and autoimmune thyroid disease (ATD) could predict thyroid malignancy. A total of 577 patients with thyroid papillary carcinoma (PTC) and 293 patients with benign MNG disease were enrolled postoperatively. Demographic features, thyroglobulin (TgAb) and thyroid peroxidase antibodies (TPOAb) and histologic outcome of the patients were evaluated. The prevalence of ATD and TgAb or TPOAb measurements was not statistically different in PTC and MNG groups. However, tumors were significantly smaller and tumor capsule invasion was seen less frequently in patients with PTC and ATD than without ATD. Patients without ATD had more advanced stage (TNM stage III/IV) tumors than with ATD. Only one of the 11 patients with distant organ metastasis had ATD. The present study demonstrated that the prevalence of ATD diagnosed even with histology or TAb positivity was not different in patients with PTC and MNG. However, having ATD might be associated with a better prognosis in PTC patients.

In inactive hepatitis B carriers, the histological activity index and NLR were found to be correlated negatively. NLR can be used as a predictor of fibrosis in combination with other noninvasive markers.

SUMMARY BACKGROUND Hepcidin is an important regulator of iron homeostasis. OBJECTIVES This cross-sectional study was conducted to evaluate the association between hepcidin and components of metabolic syndrome in patients with chronic kidney disease (CKD). DESIGN AND SETTING 103 CKD patients and 59 healthy volunteers were included in the study from the University Hospital. METHODS Serum hepcidin levels were measured by enyzme-linked immunosorbent assay (ELISA) test. As for the study parameters, age, sex, body mass index, renal diseases, serum biochemistry, complete blood count, iron and total iron-binding capacity, ferritin, high-sensitive C-reactive protein (hsCRP), C- reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated. RESULTS The mean age of the patients was 58.63 ± 11.8 years. Hepcidin level was significantly associated with hypertension and higher uric acid levels (P < 0.05). There was a positive correlation between hepcidin and urea, uric acid, creatinine, ferritin, CRP, ESR, phosphorus, triglyceride, low-density lipoprotein (LDL), proteinuria and albuminuria in 24-hour urine collection. A negative correlation was found between hepcidin and estimated glomerular filtration rate (eGFR), hemoglobin, hematocrit, calcium, 25 OH vitamin D, pH, and bicarbonate levels. CONCLUSION Hepcidin, a well-known hormone regulator of iron metabolism, may play an important role in the pathogenesis of metabolic syndrome in patients with CKD, and further studies might delineate in-depth its potential as a promising early marker in these patients.

Synovial sarcoma (SS) is a highly malignant tumor that accounts for 10% of all soft-tissue sarcomas. Primary SS arising from the lung is extremely rare, and the prognosis is poor. We report a case of pulmonary SS presenting with a mass lesion invading the right upper and middle lobes, extending to the mediastinum and the chest wall. After tru-cut biopsy, surgical resection was performed. The final diagnosis was SS (biphasic type) based on histological and immunohistochemical findings. There are no guidelines for optimal treatment due to the rarity of these tumors. Current treatment includes surgery and adjuvant chemotherapy and/or radiotherapy.

Aims Primary hyperparathyroidism (PHPT) is common disorder in which parathyroid hormone (PTH) is excessively secreted from one or more of four parathyroid glands. Primary hyperparathyroidism (PHPT) is an endocrinological disorder associated with increased systemic inflammation, endothelial dysfunction. The systemic inflammation may cause subclinical decrease in cardiac function. Our aim in our study is to compare the markers of systemic inflammation in preoperative, postoperative period with PHPT, to show that PDW (platelet distribution width) value may be a predictive value for the development of cardiovascular (CVO), thromboembolic events (TBO) in patients with primary hyperparathyroidism. Results In this study, patients who underwent parathyroidectomy for primary hyperparathyroidism between 2014 - 2021 were retrospectively screened. A total of 56 patients who underwent parathyroidectomy for PHPT were included in the study. In addition to demographic and clinical information; PTH, corrected calcium, phosphate, white blood cell (WBC) count, platelet counts and PDW of the patients were recorded before and three months after parathyroidectomy. Systemic inflammatory index (SII) was calculated according to appropriate formula. Discussion The preoperative PDW value of the patients was found to be significantly higher when compared with the postoperative period and control groups. Preoperative platelet value, on the other hand, was statistically significantly higher when compared with control group. PDW values were found to be statistically significantly decreased in the postoperative period compared to the preoperative period in patients. Conclusion Increased PDW value before parathyroidectomy may be a predictive value of inflammatıon and the development of CVO ,TBO. Keywords: primary hyperparathyroidism, PDW (platelet distribution width), platelets, parathyroidectomy It is known to cause subclinical inflammation and subclinical cardiac dysfunction in primary hyperparathyroidism. There are conflicting studies on inflammation markers. Our article is the first to study PDW in primary hyperparathyroidism. High preoperative PDW indicates that PHPT may be a risk factor for cardiovascular events.