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The tritium l a b e l l i n g of papaverine by c a t a l y t i c deshalogenation of monobromopapaverine gives a compound whereof the s p e c i f i c r a d i o a c t i v i t y i s 43 Ci/mM. Our r e s u l t s have shown t h a t only 49 X of t h i s r a d i o a c t i v i t y came from the s u b s t i t ut i o n of bromine by tritium ; 46 X are located i n the methylen group while the remaining 5 % are d i s t r i b u t e d over the o t h e r p o s i t i o n s . R6SUdLe marquage au tritium de l a papavgrine p a r dgshaloggnation c a t a l y t i q u e de l a monobromopapav6rine conduit B un p r o d u i t dont l a r a d i o a c t i v i t b spgcifique est de 43 Ci/mM. Nos r g s u l t a t s ont montrl que seulement 49 X de cette r a d i o a c t i v i t b r g s u l t e n t de l a s u b s t i t u t i o n du brome p a r l e tritium ; 46 4 s o n t l o c a l i s l s dans l e groupe m g t h y l h e t a n d i s que les 5 % r e s t a n t s s o n t r l p a r t i s s u r les a u t r e s p o s i t i o n s .