Individuals with type 1 diabetes have increased morbidity and mortality due to cardiovascular disease (CVD), being the cause of death in 40% of these patients. A high proportion develop CVD before 50 years. Objective of this study was to explore factors associated with subclinical cardiovascular disease using aortic stiffness markers including pulse wave velocity (APWv), aortic augmentation index (AIx) and carotid intima-media thickness (cIMT). Material and Methods: Cross-sectional study carried out in the Type 1 Diabetes Clinic of a tertiary center in Mexico City. Demographic and biochemical variables were evaluated. Anthropometric and body composition analysis was performed using bioelectrical impedance. Assessment of the APWv and cIMT was carried out using ultrasound and AIx with aortic tonometry. Statistical analyses were performed using SPPS version 21, a P value < 0.05 was considered significant. Results: 49 patients have been included, 25(51%)women. Mean age of the participants was 38.1±11.9 years. Mean age at diagnosis was 17± 8.8 years and time median time since diagnosis 20(range 6 to 43) 17± 8.8 years. A positive correlation was found between APWv and time since diagnosis, total cholesterol and visceral adipose tissue and a negative association with eGFR. The AIx showed positive correlation with time since diagnosis, age, body mass index (BMI) and systolic blood pressure. The cIMT showed a positive correlation with time since diagnosis, BMI and a negative association with eGFR. We did not find associations between the stiffness markers and A1c or albuminuria. In the linear regression analysis only time since diagnosis remained significantly and independently associated with the AIx after adjusting for age, BMI and systolic blood pressure. Conclusions: This preliminary report shows that time since type 1 diabetes diagnosis is positively and independently associated with markers of aortic rigidity (AIx) in this population of young adults with type 1 diabetes. Disclosure F.M. Rodriguez: None. B. Rivas: None. C. Lara: None. D. Uribe: None. A.J. Martagon: None. P. Almeda-Valdes: None. J.A. Garay Mora: None. N. Ramirez Pedraza: None.

Objective: Osteoporosis is typically identified as a disease of postmenopausal women, however; it has been observed that in patients with type 1 diabetes (T1D) fractures associated with osteoporosis four to six times more common, in both sexes and at an early age (≈ 50 years). The objective of this study was to find associations between the bone mineral density (BMD), T-score and Z-score at the femoral neck, hip and spine and selected characteristics of patients with T1D. Methods: BMD of patients with T1D was evaluated with DXA (GE Healthcare Lunar). A correlation analysis was performed to identify associations between glycated hemoglobin, 25-hydroxyvitamin D concentration, years since diagnosis and diabetic, estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (ACR). Results: We included 43 patients, with a mean age of 38.1 years, the mean BMD in the femoral neck was 0.94±0.13, in the hip 0.93±0.14 and the spine 1.11±0.13. We observed a negative correlation between the years since diagnosis of T1D and the BMD and T-score in the femoral neck and hip. There was a negative correlation between the ACR and the BMD, T-score and Z-score in the femoral neck and total hip and a positive correlation between the eGFR and the BMD and T-score in the femoral neck and hip. Conclusions: In this study we identify some factors that might impact and decrease the BMD in patients with T1D including long time since diagnosis, older age of patients and presence of diabetic nephropathy. The ACR could be an indicator of early bone metabolic changes in patients with T1D. Further studies are required to confirm this association and to define the optimal age for BMD evaluation in patients with T1D. Disclosure C. Lara: None. F. Rodriguez: None. T. Viveros-Ruiz: None. P. Almeda-Valdes: None. D. Uribe: None. B. Rivas: None. N. Ramirez Pedraza: None. J.A. Garay Mora: None.