defend different points of view on the duration of isolation for a 24-year-old patient, without comorbidities and with COVID-19. However, she required hospitalization in the Intensive Care Unit, having evolved without complications, but as she lives with her parents, she was considered to be a high risk for disease spreading. Therefore, it is essential to determine the appropriate period of isolation 1 . The reader are stimulated to choose between recommending extended isolation for 20 days or reassure the patient on the low risk of transmission. To support the discussion, there are a total of eight scientific articles published between 2020 and 2021 (a meta-analysis and seven observational studies). However, when analyzing them individually, the question arises: is there enough evidence in each of these articles to justify any of the reader's choice?The meta-analysis goal is to characterize the dynamics of viral load, the release duration of viral RNA and the release of viable SARS-CoV-2 viruses in various body fluids, in addition to comparing the viral dynamics of SAR-S-CoV-2, SARS-CoV and MERS-CoV2. Among the conclusions, the authors find that the release of SARS-CoV-2 RNA in respiratory and stool samples can be prolonged, but the duration of viral viability is reduced. Furthermore, it is said that the SARS-CoV-2 titers in the upper respiratory tract reach their peak in the first week of the disease 2 .

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Cerebral venous thrombosis is an uncommon condition in the group of cerebrovascular diseases, usually affecting young individuals. Various risk factors are reported, including thrombophilia, connective tissue diseases, cancer, drugs and head trauma. It can manifest clinically by headache, focal deficits, visual disturbances and seizures, according to the site vascular involved. There are few cases reported in literature about the association of cerebral venous thrombosis with systemic lupus erythematosus. A case of a 34 year-old femalepatient is reported whose initial sign of cerebral venous thrombosis, confirmed by computed tomography and magnetic resonance angiography of the brain, occurred with generalized tonic-clonic seizures. Patient underwent extensive workup, filling the classification criteria for SLE, according to the Guidelines of the American College of Rheumatology, 1997. Patient received therapeutic anticoagulantion and immunosuppressive therapy, being referred to outpatient treatment with the Rheumatology clinic, without recurrence of seizures.