We present a convolutional neural network architecture for performing joint design of color filter array (CFA) patterns and demosaicing. Our generic model allows the training of CFAs of arbitrary sizes, optimizing each color filter over the entire RGB color space. The patterns and algorithms produced by our method provide high‐quality color reconstructions. We demonstrate the effectiveness of our approach by showing that its results achieve higher PSNR than the ones obtained with state‐of‐the‐art techniques on all standard demosaicing datasets, both for noise‐free and noisy scenarios. Our method can also be used to obtain demosaicing strategies for pre‐defined CFAs, such as the Bayer pattern, for which our results also surpass even the demosaicing algorithms specifically designed for such a pattern.

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The evolution of cancer is inferred mainly from samples taken at discrete points that represent glimpses of the complete process. In this study, we present esiCancer as a cancer-evolution simulator. It uses a branching process, randomly applying events to a diploid oncogenome, altering probabilities of proliferation and death of the affected cells. Multiple events that occur over hundreds of generations may lead to a gradual change in cell fitness and the establishment of a fast-growing population. esiCancer provides a platform to study the impact of several factors on tumor evolution, including dominance, fitness, event rate, and interactions among genes as well as factors affecting the tumor microenvironment. The output of esiCancer can be used to reconstruct clonal composition and Kaplan-Meier-like survival curves of multiple evolutionary stories. esiCancer is an open-source, standalone software to model evolutionary aspects of cancer biology. Significance: This study provides a customizable and hands-on simulation tool to model the effect of diverse types of genomic alterations on the fate of tumor cells.