Video compression in medical video streaming is one of the key technologies associated with mobile healthcare. Seamless delivery of medical video streams over a resource constrained network emphasizes the need of a video codec that requires minimum bitrates and maintains high perceptual quality. This paper presents a comparative study between High Ef ciency Video Coding (HEVC) and its potential successor Versatile Video Coding (VVC) in the context of healthcare. A large-scale subjective experiment comprising of twenty-four non-expert participants is presented for eight different test conditions in Full High De nition (FHD) videos. The presented analysis highlights the impact of compression artefacts on the perceptual quality of HEVC and VVC processed videos. Our results and ndings show that VVC clearly outperforms HEVC in terms of achieving higher compression, while maintaining high quality in FHD videos. VVC requires upto 40% less bitrate for encoding an FHD video at excellent perceptual quality. We have provided rate-quality curves for both encoders and a degree of overlap across both codecs in terms of perceptual quality. Overall, there is a 71% degree of overlap in terms of quality between VVC and HEVC compressed videos for eight different test conditions.