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For the first time, the effectiveness of triazolinedione (TAD) click chemistry onto aliphatic polycarbonates (APC) is demonstrated. Statistic copolymers carrying click‐reactive conjugated diene (in a ratio of 10%) are synthesized via organocatalyzed ring‐opening polymerization. The highly efficient click reaction of TADs carrying simple butyl and phenyl functions are confirmed by 1H‐NMR and DSC. Network formation using a bivalent TAD is also performed and simply characterized by DSC. This post‐polymerization functionalization of biocompatible and biodegradable APC pave the way to easy and versatile “on‐demand” materials design.

The search for new in vitro screening tools for early metabolite profiling and identification is becoming a major focus of interest in the pharmaceutical industry. This is motivated by the hope to avoid late failure in drug development and ultimately to launch safer drugs with fewer side effects. Electroanalytical methods alone or coupled on-line with mass spectrometry, can find a niche in this context as they may be readily implemented for the electrically driven synthesis and characterization of xenobiotics oxidized or reduced form(s). Intimately integrated in a dual electrode-enzyme configuration, electroanalysis offers also a mean to study electron transfer at the redox active center of the enzyme in the presence of a substrate and/or an inhibitor.

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