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A new species of a new genus of the Actinomycetales was discovered, Kibdelosporangium aridum. This strain produces a new family of glycopeptide antibiotics designated aridicins, that contain an unusual glycolipid constituent. They inhibit Gram-positive bacteria, including staphylococci, enterococci and Clostridium sp. While studying organisms originating from unusual ecological niches, we isolated a new genus of the Actinomycetales that elaborated antibiotics which inhibited bacterial cell-wall synthesis. These were shown to be novel glycopeptide antibiotics named aridicins1). In this paper we will describe the new genus, Kibdelosporangium, cultural conditions for production of aridicins and the antibiotic activities of the major components of the complex. Materials and Methods Strain The aridicin producer, SK&F-AAD-216, was isolated from a soil sample collected in a desert area of Pima County, Arizona. Stock cultures were grown on agar slants of thin potato-carrot agar or oatmeal agar (ISP 3) and aliquots were stored in the vapor phase of liquid nitrogen.

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