Впервые проведены комплексные исследования по изучению цитотоксических сывороток на организм животных; разработаны методики изготовления сывороток, изучены биохимические показатели, фармакологические свойства и биологическая активность, определены наиболее оптимальные дозы и способы применения препаратов для коррекции иммунного статуса, продуктивности и репродуктивной функции животных, впервые дана оценка состояния факторов неспецифической защиты организма животных при применении цитотоксических сывороток. ANNOTATION.For the first time, complex studies were conducted on the study of cytotoxic sera on the animal organism; methods for the production of serums have been developed, biochemical indicators have been studied pharmacological properties and biological activity; the most optimal doses and methods of using drugs for the correction of the immune status, productivity and reproductive function of animals are determined; the state of factors of nonspecific protection of the organism of animals when using cytotoxic serums is assessed for the first time.

The aryicle presents the results of a comparative study of the biochemical composition of earthworms of dendrobene and prospector rocks, the peculiarities of their cultivation and their use for feeding when growing juvenile tilapia and clary catfish. The experience of cultivating earthworms of two breeds using the improved methods of foreign authors is described. The results of a study of the biochemical composition of cultivated objects that determine their nutritional value for feeding fish are presented. The fish-breeding and biological indicators of juvenile tilapia and clary catfish, obtained during the cultivation of dendrobene and prospector in fish farming in the Almaty region (VI fish-breeding zone) during worm feeding, are analyzed. A comprehensive analysis of the studied indicators made it possible to assign a certain rating place to each worm breed in relation to its use as fish feed.

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