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Organophosphate insecticides (OP) are used widely in Turkey and are the most common agent employed for suicidal poisoning. At present there are limited data available on the distribution of OP in humans, and the aim of the study was to report insecticide concentrations in human autopsy tissues. With the use of gas chromatography-nitrogen phosphorous detector, the levels of fat, liver, and blood OP were determined from 32 suicide victims. In all cases OP were present and usually more than one OP was found. The concentration of OP was highest in fat and least in blood. Even 20 d postmortem OP could be detected in human autopsy tissues, but the correlation to fat content and mortality needs to be addressed.

1990-1994 yılları arasında Adli Tıp Kurumu İzmir Grup Başkanlığı Morg İhtisas Dairesi’nde otopsisi yapılan 2740 olgunun adli tahkikat, otopsi, alkol, toksikoloji ve histopatoloji raporları incelenerek olgular yaş, cinsiyet, orijin, ölüm nedeni, toksikolojik ve histopatolojik inceleme sonuçları ile kan alkol düzeyleri yönlerinden değerlendirildi. Olguların %78.3' ü erkek, en sık rastlanan yaş grubu 20- 29'du (%22.3). Orijin olarak ilk sırayı marazi sebepler (%33-3), alırken bunu cinayetler (%28.9), kazalar (%21.9) ve intiharlar izlemekteydi. Olgulardan % 16.1’ inin kanında değişik düzeylerde alkol bulunduğu tespit edildi. Yapılan benzer çalışma sonuçları ile karşılaştırıldığında ölüm nedenleri arasında yöresel bazı farklılıklar olduğu, Türkiye genelindeki durumu ortaya koyabilmek için değişik yörelerde benzer çalışmaların yapılmasının yararlı olacağı düşünüldü.Anahtar Kelimeler: Otopsi, Postmortem Muayene.

Different kinds of organophosphorous compounds (OP) are used as pesticides in Turkish agriculture. Suicidal, accidental, or occupational exposure may occur in developing countries. OP inhibit acetylcholinesterase (AChE) activities; on the other hand, serum paraoxonase (PON1) hydrolyzes the toxic metabolites of a variety of OP. In recent years, some studies have shown that PON1 activity is an important marker in individuals who are exposed to OP. Both serum cholinesterase and PON1 activities were measured spectrophotometrically from 18 male agricultural workers who were chronically exposed to azinphos methyl, chlorpyriphos, or malathion and other pesticides during cereal spraying, transportation, and storage. The individuals were classified according to PON1 phenotypes using the antimode 60% stimulation method to determine the dividing point between non-salt-stimulated, A type (homozygotes for the low-activity allele), and salt-stimulated AB (heterozygotes) and B types (homozygotes for the high-activity allele). A positive correlation was found between AChE activities and percent of PON1 stimulation. The individuals with phenotype A had the lowest enzyme activities. This study suggests that individuals with phenotype A might be more sensitive to OP-induced toxicity.