The test drug CORSHE-E is an effective and safe cough syrup that is highly acceptable for patients with cough of short duration.

No abstract

Background Mothers' knowledge of infant and young child feeding (IYCF) play a crucial role in the overall growth and development of a child, determined by their anthropometry. Malnutrition has been linked to the short- and long-term effects on child health and, ultimately, national development. This community-based cross-sectional study focuses on the nutritional parameters of infants and young children in an urban slum population. The primary objective was to study IYCF from birth up to two years of age. The secondary objective involved studying the association between feeding practices and anthropometric measurements among children of 12-23 months of age. Methods The mothers of 96 children who were between 12 and 23 months of age, living in the urban slum of B.K Nagar, Bangalore, India, were administered the United Nations Children's Fund (UNICEF) IYCF questionnaire. Breastfeeding and complementary feeding information from these children from birth to 24 months were obtained. Anthropometric measurements were measured with appropriate calibrations. Results The population consisted of 57.3% females and 42.7% males. All children had mean anthropometric measurements below the World Health Organization Multicentre Growth Reference Study (WHO-MGRS) standard (weight for age in males, P=0.009, and females P=0.005). A delay in the initiation of breastfeeding was observed in female children (54.5%), showing a significant reduction in their weight (P=0.020) as compared to those initiated early. There was also a declining trend of continuation of breastfeeding from age 12 months to 23 months. The study revealed a high consumption of gripe water (68.8%) and bottle feeding (40.4%). A significant difference was found in children who consumed nutritious food, especially meat, with height (P=0.018) and weight (P=0.011), along with other foods. Conclusion IYCF and anthropometry have a direct association, evidence of which is reflected by the mother’s knowledge of feeding practices along with other socioeconomic parameters.

Background: β lactam antibiotics are commonly prescribed groups of antibacterial drugs for various infections however the prevalence of its allergic effects is not clear in our country, hence the need for an effective diagnostic protocol to determine immediate hypersensitivity reactions. The objective was to formulate a diagnostic protocol for evaluating immediate drug hypersensitivity to β lactam antibiotics.Methods: A prospective study was conducted at a tertiary care hospital. Adults who were prescribed any class of β lactam antibiotic were included. Non irritating concentrations of the antibiotic as per The European Network on drug Allergy were used. A strict three step diagnostic algorithm with skin prick test followed by intradermal test and drug provocation test, with 20 minutes observation period between each step, to determine cutaneous allergic reactions was followed.Results: The most commonly prescribed drug was cefazolin, followed by ceftriaxone, and cefoperazone + sulbactam combination. The culprit drugs were ceftriaxone in 4 (4.7%) patients, followed by piperacillin + tazobactam combination in 3 (3.5%), amoxicillin + clavulanic acid in 2 (2.3%) and 1 (1.1%) each for cefotaxime and cefepime + tazobactam combination. No patients were positive for skin prick test; 2.4% were positive for intradermal test and 10.6% were positive for drug provocation test.Conclusions: This diagnostic protocol is apt to adequately diagnose immediate reactions to β lactam antibiotics and henceforth can be used effectively in India. However, the skin prick test may be excluded but the intradermal test and drug provocation test is crucial to identify these immediate reactions.