This study aims to test the effect of self-efficacy on resilience with achievement motivation as a mediator variable empirically. This study's subjects were 211 students of the State Islamic University of Walisongo Semarang, who were santri. The sampling technique used was proportional stratified random sampling. The data were collected using a self-efficacy scale, a scale of achievement motivation, and a resilience scale. Self-efficacy was shown to have a significant effect both directly (beta = 0.413; p <0.01) and through achievement motivation (beta = 0.297; p <0.01) on resilience. The total effect of self-efficacy and achievement motivation on resilience was 0.710 (p <0.01). These results can be a suggestion or reference regarding the dynamics of students' resilience with the status of santri, the importance of increasing selfefficacy, and always maintaining and developing the santri' achievement motivation.