Aim and objective: The objective of the present systematic review is to evaluate the success of pulpotomy in mature permanent teeth presented with irreversible pulpitis. Methodology: The following databases were searched: MEDLINE, EMBASE, Cochrane Library, CINAHL Complete, Scopus, and ClinicalTrials.gov. We included studies published in the English language only. However, narrative reviews and case reports/series were excluded. The first electronic and hand search yielded a total of 210 articles. After going through extensive screening and eligibility process, only thirteen articles were finally selected for the review. The follow-up period ranged from 1 to 10years. A Meta- analysis of two randomized clinical trials was performed using RevMan 5.4 (RevMan 5.4, The Nordic Cochrane Centre, Copenhagen). Results: Randomized controlled trials which compared pulpotomy with the root canal treatment reported comparable success of pulpotomy. All the other studies have also shown comparable clinical and radiographic success of pulpotomy. Conclusion: Pulpotomy can be considered an alternative option for mature permanent teeth with irreversible pulpitis.

Objective: This systematic review and meta-analysis aimed to assess whether machine- assisted agitation resulted in less postoperative pain (PP) compared with syringe irrigation with needle alone in adult patients undergoing root canal treatment. Methodology: PICO strategy was used to electronically search key terms in the PubMed, Science Direct, Cochrane Library, Google Scholar and Wiley Online databases up to 2021 for randomized control trials (RCTs) with an observation period of at least 6 hours. The bias risk for RCTs was assessed using the Cochrane risk of bias tool. Meta-analysis was performed using RevMan 5.4 (RevMan 5.4, The Nordic Cochrane Centre, Copenhagen). Results: A total of 9 studies (for systematic review) including 1075 patients with a 565/530 male to female ratio and a mean age of 40.5 years met the inclusion criteria. Out of 9, 6 studies were selected for the meta-analysis. Meta-analysis of the 6 studies indicated that overall, the use of machine-assisted irrigation technique showed better postoperative pain reduction than conventional syringe irrigation. Conclusion: Overall, machine-assisted irrigation causes reduction in postoperative pain compared to conventional syringe irrigation.