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Diamond is a metastable carbon allotrope. Nanodiamond is a monocrystalline diamonds having a particle sizes of smaller than 100 nm are known as microdiamonds that has been extensively explored over the last few decades. Nanodiamonds are particularly appealing in order to provide variety of possible applications due to their superior mechanical and optical qualities, wide surface area, ease of bioconjugation, and high biocompatibility. In recent years, NDs have gotten a lot of attention in nanomedicine, and some significant progress has been made. The methods for creating various kinds of nanodiamonds are generalized, including detonation, CVD, hydrothermal and High-Pressure, High-Temperature Microdiamond Milling procedures. The characteristics, properties, synthesis, structure and surface functionalization and applications of nanodiamonds for antimicrobial activity are discussed in this review paper.

The classic autoimmune disease, myasthenia gravis (MG), is brought on by certain autoantibodies at the neuromuscular junction. A classic illustration of an antibody-mediated autoimmune illness is MG. Autoantibodies against the acetylcholine receptors are present in the majority of MG patients (AChRs). Muscle-specific kinase (MuSK), low-density lipoprotein receptor-related protein 4 (Lrp4), and agrin are among the less frequently found autoantibodies. The downregulation, destruction, functional blockage, or disruption of AChR clustering in the postsynaptic membrane are all ways in which these autoantibodies interfere with cholinergic transmission between nerve terminals and muscle fibres. Fatigable muscle weakness, which may affect the ocular, bulbar, respiratory, and limb muscles, is the primary clinical symptom of MG. Depending on the autoantibody's kind and whether a thymoma is present, there are different clinical symptoms. By changing the immune homeostasis processes that stop the onset of autoimmune disorders like MG, a number of medications, including immune checkpoint inhibitors, penicillamine, tyrosine kinase inhibitors, and interferons, may cause de novo MG. Keywords: myasthenia, gravis, diagnosis, treatment

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