Nano-TiCl 4 /SiO 2 was used as a readily available, inexpensive, efficient, and environmentally benign heterogeneous solid acid catalyst for the one-pot cascade synthesis of highly functionalized dihydro-2-oxopyrroles. Four-component reaction (4CR) of dialkyl acetylenedicarboxylates, aniline derivatives, and formaldehyde was employed for the synthesis of these compounds under thermal conditions. Graphical abstract

The title pyrroles are efficiently obtained by one-pot four-component cascade reaction of various anilines, formaldehyde, and dialkyl acetylenedicarboxylates. -(BAMONIRI*, A.; MIRJLILI, B. B. F.; TARAZIAN, R.; Monatsh. Chem. 146 (2015) 12, 2107-2115, http://dx.