Several contributions have reported an altered expression of pseudoneglect in psychiatric disorders, highlighting the existence of an anomalous brain lateralization in affected subjects. Surprisingly, no studies have yet investigated pseudoneglect in first-degree relatives (FdR) of psychiatric patients. We investigated performance on "paper and pencil" line bisection (LB) tasks in 68 schizophrenic patients (SCZ), 42 unaffected FdR, 41 unipolar depressive patients (UP), and 103 healthy subjects (HS). A subgroup of 20 SCZ and 16 HS underwent computerized LB and mental number line bisection (MNL) tasks requiring judgment of prebisected lines and numerical intervals. Moreover, we evaluated, in a subgroup of 15 SCZ, performance on LB and MNL before and after parietal transcranial direct current stimulation (tDCS). In comparison to HS and UP, SCZ showed a systematic rightward bias on LB, partially corrected by selective right posterior parietal tDCS. Interestingly, even FdR showed a lack of pseudoneglect on LB, expressing a mean error lying in the middle between those of HS and SCZ. On the other hand, our results showed no significant difference between the performance of SCZ and HS on MNL. Both groups showed a comparable leftward bias that could not be significantly altered after left or right parietal tDCS. These findings confirm the existence of reduced lateralization in SCZ, suggesting specific impaired functioning of the right parietal lobule. Notably, we report a lack of pseudoneglect not only in SCZ but also in FdR, raising the hypothesis that an inverted laterality pattern may be considered a concrete marker of schizotypal traits.

Two groups of psoriatic outpatients (ns = 192 and 119) were given, respectively, the Million Clinical Multiaxial Inventory-II and Foulds' Delusions-Symptoms-States Inventory. They were compared with dental (n = 192) and with general surgical (n = 190) patients. The psoriatic group presented clearly higher mean scores and frequencies on most of the personality disorder scales. On Foulds' inventory, psoriatic patients showed higher frequencies of neurotic and psychotic class allocations. A cluster analysis of personality scores provided evidence for 4 different personality clusters of patients with psoriasis: (a) Avoidant, Dependent, Schizoid, and Self-defeating (32.2%), (b) Compulsive, Narcissistic, and Aggressive (30.7%), (c) no personality disorder (18.2%), (d) Borderline, Paranoid, and Schizotypal, etc. (18.8%).

Foulds' inclusive non-reflexive law of symptom formation has been hitherto confirmed only on psychiatric or non-clinical persons. Given that respectively a yes-bias and a high frequency of non-classified patients may have inflated the rate of confirming protocols in these groups, a validation study was conducted with the Delusions-Symptoms-States Inventory (DSSI) on 188 psychiatric and 295 dermatological patients. Although non-classified patients were not included in the study (thus lowering the number of conforming patterns), both samples showed percentages of patterns conforming to Foulds' law which were above 85 per cent. No significant intergroup difference was found. The rate of conforming patterns in both groups was lower for members of the two psychotic classes (61-77 per cent). Foulds further hypothesized that the number of pathological sets within a given class grows if there is allocation into a superordinate class. This assumption was confirmed in both groups and for most of the inter-class comparisons. Suggestions were advanced to clarify the issue of the time span to be covered by Foulds' pyramid, to refine the instructions and the response format of the DSSI, and to include into the pyramid further relevant disturbances.

The basic hypothesis of the literature on alexithymia, i.e. that alexithymia has a higher prevalence in psychosomatic than in neurotic (and delusional) patients, was empirically tested by means of the well-validated Toronto Alexithymia Scale (TAS). Surprisingly, neurotic and delusional patients (N = 71) had significantly higher mean total scores on the TAS, compared with the psychosomatic group (N = 150); the normal control sample (N = 224) was, as predicted, the lowest scorer. This hierarchical distribution was confirmed for the first two factors of alexithymia: (1) difficulty in distinguishing between feelings and bodily sensations, and (2) difficulty in expressing feelings. The psychiatric group was, instead, the lowest scorer on the third factor (lack of fantasy life). A substantial cross-validation of the above findings was achieved by comparing on the TAS three subgroups of the normal sample (symptom-free, somatizing and 'neurotic' normal controls). The postulate of the non-neurotic nature of alexithymia, along with its many psychopathological and technical corollaries, is completely contradicted by the present findings.

Patterns of adaptation to conflict were explored with the Serial Color-Word Test, and personality disorders were assessed by means of the Coolidge Axis II Inventory in a group of 76 nonpsychotic women volunteers in the age range 18-50 yr. (M=29.1 yr., SD=8.3), who attended a psychiatric outpatients unit. Forward multiple regression analyses were performed to investigate whether patterns of adaptation were associated with personality disorders. 10 out of 13 personality scales, as measured by the Coolidge Axis II Inventory, were significantly predicted by adaptive variables. Some predictors were positive and others were negative. The variable R(AD) was a negative predictor of avoidant and dependent personalities, and a positive predictor of Extraversion, Aggressive personality, and Antisocial personality; this finding suggests that R(AD) may represent the regulative counterpart of a continuum from passive introversion to aggressive extraversion. The results encourage further research on nontrait laboratory correlates of personality disorders.