The Cissus sulcicaulis Baker species belongs to the Vitaceae family is popularly used for its anti-inflammatory activity. This study investigated for the first time the reproductive capacity of pregnant rats exposed daily to Cissus sulcicaulis Baker, the fetal organogenesis (prenatal assay), and the development of the pups (postnatal assay). Pregnant rats were exposed for the entire gestational period to a saline solution (control), Cissus sulcicaulis Baker (0.2 or 0.4 g/kg/day) and diclofenac potassium (positive control-1.0 mg/kg/day). Fertility and pregnant weight gain were monitored. Pups were monitored for body weight, offspring vitality, morphology, and physical and neurobehavioral development. Cissus sulcicaulis Baker at a dose of 0.4 g/kg/day promotes alterations in reproductive performance of pregnant rats (p<0;05); at doses of 0.2 and 0.4 g/kg/day promoted morphologic changes in the offspring parameters (p<0;05); and in the dosage of 0.2 mg/kg/day significantly promotes neurotoxicity effects in the offspring (p<0;05). In conclusion, these results indicate that the exposure of rats, during pregnancy period, to the Cissus sulcicaulis Baker proved not to be safe.