Objective Oropharyngeal squamous cell carcinoma (OPSCC) is a malignant tumor that occurs at the tongue base, soft palate, palatine tonsil, and pharyngeal wall. Few studies of OPSCC have been performed in elderly patients. Methods Patients with human papilloma virus (HPV)-related OPSCC were extracted from the Head and Neck with HPV Status Database of the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2016. We identified 355 patients with HPV-positive status, and we retrospectively evaluated elderly (≥65 years) and younger (30–64 years) patient groups to compare the differences. Results Of the 355 patients who were diagnosed with HPV-related OPSCC, 113 constituted the elderly group. Comparing the elderly group with the younger group, the 3-year HPV-positive overall survival (OS) rates were 62.4% and 70.2%, respectively, and the 5-year OS rates were 50.4% and 59.2%, respectively. Cox regression analysis demonstrated that tumor (T) stage and chemotherapy were prognostic factors for OS. Conclusion Elderly patients with OPSCC had different clinicopathological characteristics. T stage and chemotherapy should be priorities when evaluating the OS of elderly patients with OPSCC.

The environmental justice research on urban–rural exposure to flooding is underdeveloped and few empirical studies have been conducted in China. This study addresses this gap by exploring the probabilities of exposure to floods (10-, 20-, and 50-year) and examining the relationship between vulnerable groups and flooding in Nanjing, an important central city on the Yangtze River. Statistical analysis is based on multivariable generalised estimating equation (GEE) models that describe sociodemographic disparities at the census-tract level. The results revealed that (1) highly educated people in the urban centre are more likely to live in areas with high flood risk because of the abundance of education resources, and employment opportunities are concentrated in the urban centre. (2) Natives in suburban areas are more likely to live in flood-prone areas due to their favourable ecological environments near rivers and lakes. (3) Women in rural areas are more likely to live in high-flood-risk zones because most of the men are migrant workers. These findings highlight the urgent need to develop mitigation strategies to reduce flood exposure, especially in districts with high proportions of socially disadvantaged people. The linkages between rural and urban areas need to be strengthened in order to reduce flood exposure.

Background Medulloblastoma is an aggressive brain tumor mostly found in children, few studies on pathogenic germline mutations predisposing this disease was reported. Case presentation We present an 11-year-old male with medulloblastoma, who harbors a de novo PHOX2B germline mutation as detected by whole exome sequencing (WES). Family history was negative. Sanger sequencing confirmed this mutation in peripheral blood, hair bulbs, urine and saliva. Identification of novel germline mutations is beneficial for childhood cancer screening. Conclusions This case revealed a de novo PHOX2B germline mutation as a potential cause of medulloblastoma in a child and suggests familial germline variant screening is useful when an affected family is considering having a second child.