A Z-scheme I-BiOCl/N-GQD (i.e., nitrogen-doped graphene quantum dot) heterojunction was prepared by a one-pot precipitation method at room temperature. The doped iodine decreased the band gap of BiOCl, the introduced N-GQDs enhanced light harvesting and prolonged the photogenerated electron lifetime, and the resultant Z-scheme heterojunction promoted the spatial separation of interfacial charges. Thus, the composite showed high photoelectrochemical activity and a big cathodic photocurrent signal. On the basis of the coordination of chlorpyrifos with surface Bi­(III) of the composite, a cathodic photoelectrochemical sensor was constructed for the selective detection of chlorpyrifos. In this case, chlorpyrifos decreased the lifetime of photogenerated electrons, so the photocurrent became small. Furthermore, the photocurrent changed and the logarithm of chlorpyrifos concentration presented a linear relationship. The linear range was 0.3–80 ng mL–1, and the limit of detection was estimated to be 0.01 ng mL–1 (defined as S/N = 3). The present strategy can also be used for the design and fabrication of other PEC sensors suitable for different analytes.

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A novel Z-scheme BiOI–CdS photocatalyst was prepared based on an electrostatic interaction mechanism and it showed excellent selectivity and extended linear range for Cu2+ detection.

Purpose: To investigate the impact of hyperglycemia during inductive treatment on the prognosis of acute lymphocytic leukemia (ALL) in children. Materials and Methods: Clinical data of 159 ALL childhood cases were reviewed. The patients were divided into the hyperglycemia group (fasting glucose≥126mg/dl and/or random blood glucose≥200mg/dl) and the euglycemia group according to the blood glucose values. The Χ2 test was performed to compare the complete remission rates of the two groups, and Kaplan-Meier and log-rank tests were performed to compare the 5-year overall and relapse-free survival. Results: The incidence of hyperglycemia in the age≥10-year-old group was higher than the younger-age group (P=0.009). Values in the interim-and high-risk groups were higher than the standard-risk group (P=0.028), while there was no significant difference between genders (P=0.056). The complete remission rates of the 2 groups demonstrated no significant difference (P=0.134), while the 5-year OS of the hyperglycemia group was lower than in the euglycemia group (83.8±6.0% vs 94.9±2.4%, P=0.014). The 5 -year RFS was significantly lower than the euglycemia group (62.9±8.7%) vs 80.2±9.1%, P<0.001). Conclusions: Children with age≥10 years old, and in the middle-and high-risk groups appear prone to complicating hyperglycemia during inductive chemotherapy, associated with lower 5-year OS and RFS.Keywords: Childhood ALL -chemotherapy-related hyperglycemia -relapse-free rate -overall survival RESEARCH ARTICLE Impact of Chemotherapy-Related Hyperglycemia on Prognosis of Child Acute Lymphocytic LeukemiaBi-Hong Zhang 1 , Jian Wang 1 , Hong-Man Xue, Chun Chen* the L-asparaginase (L-asp) and glucocorticoids are the commonly used drugs during the child ALL inductive chemotherapy, which would affect the production, release and functions of insulin, the chemotherapy-related hyperglycemia is also a common complication of child ALL, with the occurring rate as 4% to 20%, or even as high as 56% (Belgaumi et al., 2003;Sonabend et al., 2008). Currently, the report about the impacts of hyperglycemia during the inductive chemotherapy towards the prognosis of child ALL is few, and the conclusions are inconsistent. This study compares the rates of complete remission, 5-year recurrence-free survival and 5-year overall survival between the hyperglycemic ALL children and the non-hyperglycemic ALL children during the inductive chemotherapy, aiming to analyze the relationship of hyperglycemia and prognosis of child ALL.