Highlights Coronavirus disease 2019 (COVID-19) has emerged as a global health threat. The direct effects of the virus (SARS-CoV-2) on the nervous system are largely unknown. Research on earlier coronavirus infections (SARS, MERS) shows they are neurotropic. Delirium, anosmia, acute behavioral changes, stroke and encephalopathy are common complications of COVID-19. Current and long-term neuropsychiatric effects of COVID-19 and possible pathogenesis are reviewed.

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Our findings suggest involvement of multiple WM tracts in juvenile OCD. In addition to the widely proposed hypothesis of orbitofrontal-striato-thalamo-cortical circuitry deficits in the development of OCD, our findings suggest involvement of additional brain regions, possibly parietal cortex, lateral prefrontal cortex, and limbic system. The widespread differences in WM among cases and controls also points to the possibility of underlying myelination changes.

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