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This work reports a novel, simple and robust flow cytometric method of characterization of protein aggregates of different size and composition which would find wider application in characterization of biomolecular aggregates, in general.

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We have designed and optimised a combined laser pulse using optimal control theory-based adaptive simulated annealing technique for selective vibrational excitations and photo-dissociation. Since proper choice of pulses for specific excitation and dissociation phenomena is very difficult, we have designed a linearly combined pulse for such processes and optimised the different parameters involved in those pulses so that we can get an efficient combined pulse. The technique makes us free from choosing any arbitrary type of pulses and makes a ground to check their suitability. We have also emphasised on how we can improve the performance of simulated annealing technique by introducing an adaptive step length of the different variables during the optimisation processes. We have also pointed out on how we can choose the initial temperature for the optimisation process by introducing heating/cooling step to reduce the annealing steps so that the method becomes cost effective.

Photo dissociation dynamics of diatomic molecular ion HBr+ interacting with ultra fast laser pulses of different envelop function has been presented both in zero and non zero temperature environment. The calculations pertain primarily to the ground electronic state of the molecular ion HBr+. The used potential of HBr+ is calibrated with the help of the ab initio theoretical calculation at the CCSD/6-311++G(3df, 2pd) level and then fitted with appropriate Morse parameters. The numerical bound states vibrational eigenvalues obtained by the time independent Fourier Grid Hamiltonian method have been compared with analytical values of the fitted Morse potential. The effect of temperature, pulse envelops function, and light intensity on the dissociation process has been explored.