Background and Objective Excessive daytime sleepiness (EDS) is an important public health issue requiring adequate screening and management to avoid such harmful consequences. The study aimed to assess the prevalence and risk factors of EDS in the perinatal period.Methods Institution-based cross-sectional study was carried out in selected public health institutions of Ethiopia on systematic selected 362 women during perinatal period. We used a validated Epworth daytime sleepiness tool to collect data. Epi-Info^TM 7 and SPSS version 26 were used for data entry and analysis, respectively. Bivariable and multivariable binary logistic regression analyses were conducted to determine the associated factors.Results The prevalence of EDS was 16.6% (95% CI: 12.6–20.7). Excessive pregnancy-related concern (adjusted odds ratio [AOR] = 0.232, 95% CI: 0.087–0.621), having depression symptoms (AOR = 8.045, 95% CI: 3.375–19.174), anxiety symptoms (AOR = 4.905, 95% CI: 2.083– 11.550) and having a chronic medical illness (AOR = 5.441, 95% CI: 2.273–13.021) were the factors associated with EDS.Conclusions The results of the current study suggested that perinatal EDS among women in northern part of Ethiopia is a highly prevalent and associated with excessive pregnancy concern, depression, anxiety, and medical illness.