This review is based on technological trends in IgG purification. Various techniques have been developed to separate antibodies from complex mixtures. Among them are the nonchromatographic and chromatographic techniques. The former consist of techniques such as precipitation, liquid to liquid extraction, and high performance tangential flow filtration. While the latter consist of anion exchange, cation exchange, hydrophobic interaction, immobilized metal affinity, mixed-mode, and bio affinity chromatography. The article also throws light on emerging trend of formulating process buffers to prevent anomalies in the antibodies being purified.