In the present work, we propose the multi-acupoint electrical stimulation (stimulating the Láogóng point (劳宫PC8) and acupuncture points on waist, shoulders, buttocks of the human body) combined with music conditioning (MESCMC) to alleviate driving fatigue. In our study, the complexity of α and β rhythms of EEG of the drivers, the relative power spectrum of θ and β, as well as two relative power spectrum ratio θ/β and (θ+α)/(α+β) are used as fatigue features during driving. The features of the complexity, which can effectively reflect brain activity information, were used to detect the change of driving fatigue over time. Combined with the traditional relative power spectrum features, the changes in driving fatigue features were comprehensively analyzed. The results show that the MESCMC method can effectively alleviate the mental fatigue of drivers. Besides, compared with the single-acupoint electrical stimulation[only stimulating the Láogóng point (劳宫PC8)] (SES) method, the MESCMC method is more effective in relieving driving fatigue.The mitigation equipment is low in cost and practical, and the MESCMC method is individualized and improves the universality of driving fatigue detection and relieve, so will be practical to use in actual driving situations in the future.
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