No abstract

cervical cancer is the 4th most common malignant tumor type affecting women worldwide; however, its molecular mechanisms are not fully understood. Previous studies have indicated that micrornas (mirs) serve crucial roles in the cellular functions of tumors. mir-96 is involved in the tumorigenesis of many cancer types. The aim of the present study was to investigate the role and mechanism of mir-96 in the progression of cervical cancer. The present results suggested that overexpression of miR-96 significantly enhanced the proliferative, migratory and invasive abilities of cervical cancer cells, while inhibiting mir-96 had the opposite effects. additionally, activation of the akt/mTor signaling pathway was enhanced by mir-96 overexpression, while it was inhibited by the miR-96 inhibitor. Moreover, it was identified that mir-96 may directly target caveolin-1 (caV-1) to decrease its expression level. Furthermore, overexpression of caV-1 could reverse the increase in cell proliferation, migration and invasion induced by mir-96, as well as the upregulation of the akt/mTor signaling pathway. in conclusion, the present results suggested that mir-96 may have an oncogenic role in the progression of cervical cancer by targeting caV-1. Therefore, mir-96 may be a potential target for cervical cancer therapy.