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Abstract. Ovarian cancer is one of the most common malignant gynecological cancers. Although conventional chemotherapies have improved the treatment of patients with ovarian cancer, the mortality rate remains high. Hence, it is crucial that the detailed mechanisms that promote ovarian cancer are urgently identified. Therefore, reverse transcription-quantitative polymerase chain reaction was used to reveal the relative transcript levels. Colony formation assay and cell cycle assay were performed in siRNA-treated cells. Transwell assay and western blot assays were also conducted. The results showed that the expression of long non-coding RNA SRY-box 2 overlapping transcript (SOX2OT) was upregulated in clinical ovarian cancer tissues and in cultured ovarian cancer cells (HO-8910 and HO-8910PM). High expression of SOX2OT negatively correlated with the prognosis of patients with ovarian cancer. Knockdown of SOX2OT by specific small interfering RNA against SOX2OT suppressed the colony formation capacity of invasive ovarian cancer cells and resulted in cell cycle arrest in G0/G1 phase. Key cell cycle regulators, cyclin B1 and cell division cycle 25C, were consistently downregulated by the knockdown of SOX2OT. Furthermore, knockdown of SOX2O Tinhibited cell migration, cell invasion and decreased the expression of mesenchymal protein N-cadherin, whereas the expression of epithelial protein E-cadherin was increased in ovarian cancer cells. Overall, SOX2OT expression levels correlated with the prognosis of patients with ovarian cancer, and SOX2OT promoted cell proliferation and motility in ovarian cancer cells. These findings indicated that SOX2OT may serve as a potential therapeutic target in the treatment of ovarian cancer.

Permanent magnetic fault-tolerant motors have been developed rapidly due to their high reliability and have been widely used in many special fields. Compared with the conventional module faulttolerant motor, the module combined stator permanent magnetic fault-tolerant motor (MCS-PMFTSM) with unequal span winding has two sizes of span coils in each operation module, which realizes the electrical decoupling and mechanical decoupling between the module motors and solves the problem that the span of the double-layer winding of the conventional modular fault-tolerant motor can only be 1. Winding parameters of the unequal span are calculated, on the basis of which the operation performance of MCS-PMFTSM can be analyzed. The performance of MCS-PMFTSM in the normal operation and three failure operations (open circuit failure, Short circuit fault, concurrent failure) are analyzed by finite element method, which proves that it has good fault tolerance. The 12kW100r/min MCS-PMFTSM prototype is tested to verify the correctness of the analysis method and the rationality of the proposed MCS-PMFTSM.

To solve the problems of large-size machining and complex control of fault-tolerant permanent magnet machines, a module-combined stator permanent magnet synchronous machine is proposed in this paper. The winding of the module-combined stator has two forms: large and small spans. The independent power supply of each module is adopted to decouple the electricity between each module, which enhances the manufacturing flexibility and the fault-tolerant ability of the motor. A mathematical model of the module-combined stator permanent magnet synchronous machine is established, and the design method of the machine is summarized. Then the analytical formula of the radial force acting on the stator under asymmetric operation is deduced. In addition, the torque-angle characteristics of the machine and the factors affecting the radial force are studied. Finally, the machine is prototyped, and both simulation and experiment are used verify the rationality of the proposed design.INDEX TERMS Module-combined stator, asymmetric operation, torque-angle characteristic, fault-tolerant.