No abstract

A cross-sectional study was conducted on 1,200 Khmer people aged 25-64 years living in Tra Vinh province to propotion of hypertension some related factors. 30 communes (clusters) were selected by probability proportional to size (PPS) method, evaluating their risk factors of coronary artery disease (CAD) in the next 10 years using Framingham scale in face-to-face interviews. Results showed that propotion of hypertension was 33.5%, inside, having 37.3% people don't know that they are getting hypertension disease. About some risk factors: 83.6% of participants had diet with less fat, 26.2% had adequate fruit and vegetable consumption, 10.6% had less-salt diet, 85.2% were non-alcohol abuse, 62.5% were non-smokers and 79.3% had moderate physical activity. About coronary artery disease: 79.7% of respondents have low risk, 16.3% with moderate risk and 4.0% with high risk of CAD in the next 10 years according to Framingham scale. The risk increases proportionally to the age and higher among men than women.

No abstract

BackgroundChronic granulomatous disease (CGD) is an inborn error of immunity (IEI) disorder that results from defects in the respiratory burst activity in phagocytes, leading to the inability to kill bacterial and fungal microorganisms. CGD patients usually have a high incidence of morbidity such as infections and autoinflammatory diseases and a high mortality rate. Allogeneic bone marrow transplantation (BMT) is the only definitive cure for patients who suffer from CGD.Case presentationWe report the first transplant case of chronic granulomatous disease in Vietnam. A 25-month-old boy with X-linked CGD underwent bone marrow transplantation from his 5-year-old, full-matched human leukocyte antigen (HLA)-carrier sibling after myeloablative conditioning regimen with busulfan 5.1 mg/kg/day for 4 days, fludarabine 30 mg/m2/day for 5 days, and rATG (Grafalon-Fresenius) 10 mg/kg/day for 4 days. Neutrophil was engrafted on day 13 posttransplant, donor chimerism was 100% on day 30 with the dihydrorhodamine-1,2,3 (DHR 123) flow cytometric assay test that reached 38% of the normal 45 days posttransplant. Five months after transplant, the patient was free of infection with stable DHR 123 assay at 37%, and donor chimerism remained 100%. No sign of a graft-versus-host disease had been observed posttransplant.ConclusionWe suggest that bone marrow transplantation is a safe and effectual cure for CGD patients, especially for patients with HLA-identical siblings.