Botulinum toxin is a neurotoxin that has been utilized to induce chemo-denervation of muscles. Cutaneous wounds represent a special situation in which the tensile forces applied by these muscles on wound edges might have deleterious effects on the healing process. The aim of this review was to investigate such an effect and to review other mechanisms this toxin might have on the healing process. We also reviewed the role of botulinum toxin in the management of hypertrophic scars and cleft lip repair.

Two clinical forms of ulnar polydactyly are recognised in the literature, viz the African and the Caucasian forms. The current study investigated the clinical and radiological features of ulnar polydactyly in 94 Saudi patients. The incidence of ulnar polydactyly was one in 1000 live births. There were 41 males and 53 females. Positive family history, syndromal cases, associated hand anomalies, polydactyly of the little toe and systemic abnormalities were seen in 11%, 6%, 5%, 29% and 23% of cases, respectively. There were 50 unilateral (53%) and 44 bilateral cases (47%). In unilateral cases, the left hand was more commonly affected. Using a modified Rayan-Frey classification, the majority of cases were classified as Type II (pedunculated polydactyly, 52 (55%) cases) and Type III (a functioning and articulating extra digit without complete duplication of the metacarpal, 29 (31%) cases). It was concluded that the Saudi clinical presentation of ulnar polydactyly is somewhat different epidemiologically and lies between the African and Caucasian forms.

Obesity is associated with high risk and poor prognosis of breast cancer (BC). Obesity promotes BC cells proliferation via modulating the production of adipokines, including adiponectin (anti-neoplastic adipokine), leptin (carcinogenic adipokine) and inflammatory mediators. In the present study we investigated the anti-proliferative effects of liraglutide (LG; anti-diabetic and weight reducing drug) on MCF-7 human BC cells cultured in obese adipose tissue-derived stem cells-conditioned medium (ADSCs-CM) and whether this effect is mediated via modulating the adipokines in ADSCs and cancer cells. Proliferation was investigated using AlamarBlue viability test, colony forming assay and cell cycle analysis. Levels and expression of adipokines and their receptors were assayed using ELISA and RT-PCR. LG caused 48% inhibition of MCF-7 proliferation in obese ADSCs-CM, reduced the colony formation and induced G0/G1 phase arrest. LG also decreased the levels of inflammatory mediators, suppressed the expression of leptin, while increased mRNA levels of adiponectin and their receptors in obese ADSCs and cancer cells cultured in obese ADCSs-CM. In conclusion, LG could mitigate BC cell growth in obese subjects; therefore it could be used for clinical prevention and/or treatment of BC in obese subjects. It may assist to improve treatment outcomes and, reduce the mortality rate in obese patients with BC.