Background:Sickle cell disease is the commonest inherited hemoglobinopathy. There are few reports point towards decrease incidence of diabetes mellitus in sickle cell disease patients.Materials and Methods:This cross-sectional study was conducted in VIMSAR, Burla, Odisha between Nov 2014 to Oct 2016. FBS and 2 hours OGTT reports of adult sickle cell disease patients were compared with the same reports from equal no of adult persons without sickle cell disease (controls) to found out any significant difference in prevalence of diabetes mellitus in sickle cell disease patients versus controls.Results:A total of 137 adult patients of sickle cell disease out of which males were 94 (68.61%) and females were 43 (31.38%) with an average age of (26.7 ± 10.9) years and an equal number of controls [males 87 (63.8%) and females 50 (36.5%)] with an average age of (47.6 ± 13.6) years were included in the study. We found diabetes mellitus in 2 (1.46%) out of 137 sickle cell disease patients with an average BMI 18.5 kg/m2 versus 12 (8.76%) in equal number of controls with an average BMI of 22.6 kg/m2.Conclusion:This study concludes that prevalence of diabetes mellitus in sickle cell disease patients is significantly lower than non-sickle cell disease persons. This may be due to less longevity and low BMI in sickle cell disease patients.

Background: Type 2 diabetes mellitus (T2DM) occurs when impaired insulin effectiveness is accompanied by decreased insulin production by β cells. With 366 million people diagnosed in 2011 and a trend of increasing prevalence worldwide (Lyssenko and Laakso 2013), diabetes is one of the major threats to human health. Objectives of the study were to assess the occurrence of diabetes mellitus in sickle cell disease (SCD) patients and to study glycemic status of patients with SCD and clinical presentation.Methods: An observational study was done at department of general medicine and sickle cell clinic and molecular biology laboratory, Veer Surendra Sai institute of medical science and research, Burla between November 2014 to October 2016. All recorded data analyzed through standard statistical methods including standard diagram and groups and finding were discussed in detail to draw appropriate conclusion, through standard statistical methods including standard diagrams.Results: The study was taken on 137 cases of SCD patients admitted at VIMSAR, Burla. Sex distribution of SCD patient with male (68.81%) and female (31.38%) clinical feature of SCD patients shows VOC (vaso occlusive crisis) was the most common presentation for hospital admission followed by fever, anemia, jaundice, AVN (avascular necrosis), osteomyelitis, dactylitis. The most of SCD are having normoglycemic with most of diabetes mellitus are in control group. Glycemic status in SCD cases and controls with 6.57% cases of SCD, 13.14% of controls are hyperglycemic.Conclusions: The majority of patients in this SCD patients were between the age group 15-20 years. The occurrence of diabetes mellitus in SCD patients is low in compare to control population. Showing impairment of glucose tolerance in SCD but low presence of diabetes mellitus. presence of lower life span of RBC, hypermetabolic state and low body mass index in SCD patients.

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