This review stated that plants are valuable sources for new compounds and should receive special attention in research strategies to develop new antimicrobials urgently required in the near future. The importance of medicinal plants and traditional health systems in solving the health care problems of the world is gaining increasing attention. Because of this resurgence of interest, the research on plants of medicinal importance is growing phenomenally at the international level, often to the detriment of natural habitats and protects populations in the countries of origin. In Ethiopia since many years the peoples are using plants as the medicine. The plant contains various phytochemical, which would act on the pathogenic microorganism and hinder their growth. The scanty of review are available on antibacterial activity of medicinal plants in Ethiopia, but still we need to explore many antimicrobial compounds from plants. These kinds of the review are baseline information for the development of new drugs, which is bench mark in science. Commercially many synthetic drugs are available in market, but microorganisms are resistant to many antibiotics. So research should need to develop new synthetic compound from the plant source.

The Croton macrostachyus is used for the treatment of malaria, venereal diseases, cough, diabetes, constipation, tape worms and hepatitis. The dichloromethane extract of the stem bark of Croton macrostachyus was afforded two Terpenoids: the compound with full structure which is a triterpenoid and a compound with a partial structure which is a tetratrpenoid. Structural determination was accomplished by means of spectroscopic methods (IR, UV, 1D and 2D NMR).