ABSTRACIA common phenomenon in capillary electrophoresis is electroendosmotic flow (EOF). Although often useful, EOF fluctuations introduce. extra variances in the overah reproducibility of the analysis. In order to correct for these fluctuations, an on-line EOF monitoring method is required. The method presented utilixes a conductivity cell as the ground electrolyte reservoir, tilled with dilute running buffer. During the separation the. EOF will cause a continuous Sow of non-diluted buffer into this reservoir. From the resulting continuously rising conductivity signal, the EOF can be calculated and used for, e.g., migration time and peak area corrections.

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