The treatment of patients with chronic wounds and pain can be frustrating and filled with potential for medication abuse and addiction. In an attempt to improve the management of this chronic wound pain, a gel containing 4% lidocaine in TRI-726 matrix (lidocaine gel) was evaluated in 33 patients with various types chronic painful wounds. In this weeklong study, the new lidocaine gel was applied once on day 0 and patients recorded their perceived pain level for the next 7 days. Mean reported pain scores and pain intensity difference (PID) were statistically significantly lower on days 1-4 compared to day 0 and days 5-7. This new lidocaine gel was effective in reducing the pain in the majority of patients for multiple days after one application. Further studies are warranted to see if longterm use will reduce the amount of pain medication prescribed in this group of patients.