The present study aimed to describe the characteristics of patients with hematological neoplasms and COVID19, treated in a reference center in Mexico City, as well as their mortality and the factors that could influence it.Patients and methods: This retrospective study included 56 patients with hematological neoplasms and SARS-CoV-2 infection. The impact on overall survival (OS) of sex, age, malignancy status, diabetes mellitus, obesity, overweight, neutrophil count, lymphocyte count, CO-RADS was evaluated.Results: Overall mortality was 50%. Univariate analysis identified age >50 years, history of hypertension, diabetes, and a CO-RADS score >5 as factors influencing the mortality of patients with hematologic malignancies and COVID19. Multivariate analysis only identified CO-RADS score > 5. Conclusion:The mortality of patients with hematological neoplasms and COVID19 was high in our setting. Frequent co morbidities in our population can influence mortality.