Bone resorption appears to be dependent on a range of processes. It requires an adequate number of osteoclasts to access bone mineral. These osteoclasts must be activated by a mechanism which is dependent upon prior osteoblastic stimulation. A range of factors then contribute to the formation of a functionally effective resorptive hemivacuole. These entail osteoclast adhesion to the bone surface leading to the formation of a sealing zone. Only then can subsequent processes such as H+ ion transport, enzyme secretion and matrix digestion become effective. Thus, any one process is potentially limiting to resorption and is a potential target for regulation. Long-range regulation takes place through the action of hormones, of which the mode of action of calcitonin has been the subject of recent investigations in isolated osteoclasts. Such studies have shown a possible involvement of distinguishable receptor subtypes, the occupancy of which may activate at least two types of triggering mechanism. It is likely that an eventual influence on motility properties through G protein mediation accounts for the actions of this hormone and of related peptides such as amylin and CGRP at the cellular level. Similar pathways may contribute to shorter range modulation of osteoclast activity by increases in ambient Ca2+. Finally, there is recent evidence for a contribution of endothelial cell-derived product to osteoclast regulation.

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As historicist as it is materialist, my dissertation both reads the fictional queens portrayed in romance against the fraught positioning of historical queens such as Isabella of France, Anne of Bohemia and Margaret of Anjou, and traces the ambivalent function in late medieval English society of objects including the sacring-bell, the Lollard bible and the royal sword. Merging the traditionally historicist field queenship studies with typically postmodern fields like thing theory and sound theory, I investigate how queens in late medieval romances coopt, queer and reconfigure material objects of masculine power. Each chapter examines a literary queen typically dismissed by subject-oriented ontologies as insubstantial. Analyzing romances that include Richard Coer de Lyon, Chaucer's Man of Law's Tale, Malory's Morte D'Arthur and the Marian romance of "The Child Slain by Jews" from the Vernon Manuscript, I argue for the overlooked significance of literary queens as figures whose circulation illuminates the construction of medieval masculinities. Through contact with charged material objects that are pivotal to romance plots, queens query patriarchal materials, exposing their underlying "thingness" and malleability. Whether tracking the disturbing afterlife of a church bell used to exorcise the hero's queen mother in Richard Coer de Lyon, or analyzing links between the "Britoun book" that rescues Chaucer's Custance and Anne of Bohemia's vernacular books, my chapters tell a new story about the foreign queens of late medieval English romances by showing how they blur boundaries between male and female, subject and object, West and East, priest and parish, Christian and Jew, orthodox and heterodox, mother and child.

A review was conducted on 34 patients treated with intravenous ifosfamide for relapsed, inoperable carcinoma of the cervix between 1988 and 1996. The median age of patients was 44 years. Thirty-two patients had squamous cell carcinoma and 2 had adenocarcinoma. Radiotherapy had been used in primary management in 33, neo-adjuvant platinum chemotherapy in 7, and previous palliative chemotherapy in 11. Symptomatic response was assessed with respect to the symptom requiring palliaton. 25 patients failed to complete 6 cycles of chemotherapy: due to progressive disease in 14, lack of symptom response in 2, and toxicity in 11 of whom 7 had encephalopathy sufficient to abandon treatment. 32 patients were evaluable for objective response. Pathologic complete response (CR) was achieved in 1 patient, and partial response (PR) was achieved in 3 patients. The objective response rate was 11.8%. Symptomatic response throughout treatment occurred in 8 patients (24%); objective response was seen in only 3 (1 CR, 2 PR) of them and progressive disease in the remaining 5. Response duration in the 4 objective responders was 25 months in the patient with CR and 4, 6 and 8 weeks in the 3 patients with PR. In conclusion, ifosfamide, as given, is associated with unacceptable toxicity and insufficient symptomatic efficacy for use as a palliative treatment in patients with relapsed carcinoma of the cervix.