BackgroundAsthma is the most common chronic disease in children. The aim of this study was to assess the association between asthma severity and skin test reactivity to common inhalant allergens.MethodsWith informed parenteral consent, we included children with asthma, who attended for the first time to Allergy Department and collected data on clinical history, respiratory function and allergic sensitization. Asthma severity was classified using the GINA guide. We integreted the data into regression models to identify allergen sensitization most strongly associated with asthma severity.ResultsWe included 260 children with ages ranging from 3 to 18 years old (mean 11.5 ± 2.85). Male/female ratio: 1.4:1. 72.3% had mild asthma; 23.8% moderate asthma and 3.8% severe asthma. Skin prick testing with aeroallergens was performed. Most of the children were sensitized to at least one aeroallergen (89.6%). Male gender and the number of positive skin tests correlated to asthma severity. Among allergic children 72.1% had more than one allergic disease. Total serum IgE did not correlate with the number of sensitizing aeroallergens, neither with asthma severity. Dust mite was the most frequent sensitization. Cat and molds were associated with a greater risk of having moderate and severe asthma. We found a progressive sensitization with age.ConclusionsSensitization to some perennial indoor allergens, particularly cat and molds, were strongly associated with asthma severity.

Antecedentes: La alergia a proteínas de leche de vaca es la alergia alimentaria más frecuente y su prevalencia se ha incrementado en la última década. Aunque la mayoría de los pacientes presenta síntomas por ingestión, se ha descrito sensibilización cutánea y de mucosas.Caso clínico: Hombre de 31 años, chef de profesión, en quien se iniciaron síntomas orofaríngeos después de la ingesta de leche. No suprimió de su dieta otros productos lácteos que toleraba en ese momento, sin embargo, los cuadros alérgicos fueron progresando y se añadieron manifestaciones cutáneas; finalmente presentó anafilaxia por contacto con masa de pan que contenía mantequilla y leche. El paciente fue atendido en urgencias, donde se comprobó la elevación de la triptasa sérica. Las pruebas cutáneas y serológicas resultaron positivas para leche y sus derivados.Conclusión: La anafilaxia por contacto con leche es infrecuente y solo se ha informado en niños. Consideramos que la manipulación repetida de alimentos pudiera favorecer la sensibilización cutánea en adultos con historia personal de atopia.

Th2 predominates in mycosis fungoides. Given that dialyzable leukocyte extract reinforces the Th1 profile, it was unlikely for it to reactivate the disease, but the diversity of lymphocyte immunophenotypes in mycosis fungoides and the complex activation networks caused a paradoxical reactivation.