Hybrid methylammonium lead tribromide (MAPbBr 3 ) perovskite has attracted great attention in ionization radiation detection. However, the charge collection remains a challenge. Here, fast response and high-sensitivity Xray detection based on MAPbBr 3 single crystals with a surface barrier Schottky diode has been achieved at room temperature. The Schottky surface barrier can overcome the large leakage current at a high electrical field, enabling us to reduce the noise and increase the charge collection efficiency. This surface barrier device has been demonstrated a 3 times improvement over the photoconductor based X-ray detector, which enables usage in nuclear medicine, especially for X-ray imaging technology.

P-type CuI semiconductor films were deposited on the quartz substrates by vacuum evaporation technique, and their morphology, chemical stoichiometry, structure and photoluminescence (PL) characteristics were investigated. The results indicated that, by iodine annealing, the 422 nm emission of the film was improved, whereas the 720 nm emission was reduced, and a (111) preferred orientation in the film was kept unchanged. Through analyzing the time-dependent PL spectrum and the conductivity of the iodine annealed CuI film, the origin of the 422 nm emission was proposed to be related to the copper vacancy. This mechanism was further confirmed by the luminescence characteristics of the film deposited on Cu substrate.

AbstractA majority of the patients with advanced prostate cancer initially respond to androgen deprivation therapy and enzalutamide therapy, but eventually enter the castration-resistant prostate cancer (CRPC) phase. Some studies have shown that the activation of other signalling pathways in CRPC cells replaces the function of the androgen receptor, as well as promotes cell metastasis and progression. However, the mechanisms underlying this side effect remain unclear. The present study aims to explore the continued progression of cells after enzalutamide resistance. Low expression of circRNA-UCK2 (circUCK2) was detected in enzalutamide-resistant (EnzR) cells. Moreover, miR-767-5p was found to be resistant to EnzR cells when the level of circUCK2 is increased. The decrease in free miR-767-5p increases the expression of TET1 protein through the post-transcriptional regulation of mRNA, thereby inhibiting cell invasion and proliferation. Knocking down circUCK2 in enzalutamide-sensitive cells reduces the concentration of TET1, thereby increasing cell invasion and proliferation. A preclinical study using in vivo mouse models also showed that a high expression of circUCK2 inhibited the EnzR cell growth. Thus, this study might aid in developing a novel therapy to better suppress the CRPC progression.

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