Reconciliation is a necessary step in postprocessing of continuous-variable quantum key distribution (CV-QKD) system. We use globally coupled low-density parity-check (GC-LDPC) codes in reconciliation to extract a precise secret key from the raw keys over the authenticated classical public channel between two users. GC-LDPC codes have excellent performance over both the additive Gaussian white noise and binary-erasure channels. The reconciliation based on GC-LDPC codes can improve the reconciliation efficiency to 95.42% and reduce the frame error rate to 3.25 × 10–3. Using distillation, the decoding speed can achieve 23.8 Mbits/s and decrease the cost of memory. Given decoding speed and low memory usage, this makes the proposed reconciliation method viable approach for high-speed CV-QKD system.