Colorectal adenocarcinoma originating in intestinal glandular structures is * Corresponding authors Email addresses: k.sirinukunwattana@warwick.ac.uk (Korsuk Sirinukunwattana), n.m.rajpoot@warwick.ac.uk (Nasir M. Rajpoot) Preprint submitted to Medical Image AnalysisAugust 30, 2016the most common form of colon cancer. In clinical practice, the morphology of intestinal glands, including architectural appearance and glandular formation, is used by pathologists to inform prognosis and plan the treatment of individual patients. However, achieving good inter-observer as well as intra-observer reproducibility of cancer grading is still a major challenge in modern pathology. An automated approach which quantifies the morphology of glands is a solution to the problem. This paper provides an overview to the Gland Segmentation in Colon Histology Images Challenge Contest (GlaS) held at MICCAI'2015. Details of the challenge, including organization, dataset and evaluation criteria, are presented, along with the method descriptions and evaluation results from the top performing methods.

The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis counting is laborious, subjective and may suffer from low inter-observer agreement. With the wider acceptance of whole slide images in pathology labs, automatic image analysis has been proposed as a potential solution for these issues. In this paper, the results from the Assessment of Mitosis Detection Algorithms 2013 (AMIDA13) challenge are described. The challenge was based on a data set consisting of 12 training and 11 testing subjects, with more than one thousand annotated mitotic figures by multiple observers. Short descriptions and results from the evaluation of eleven methods are presented. The top performing method has an error rate that is comparable to the inter-observer agreement among pathologists.

Abstract-Colonoscopy is the gold standard for colon cancer screening though still some polyps are missed, thus preventing early disease detection and treatment. Several computational systems have been proposed to assist polyp detection during colonoscopy but so far without consistent evaluation. The lack of publicly available annotated databases has made it difficult to compare methods and to assess if they achieve performance levels acceptable for clinical use. The Automatic Polyp Detection subchallenge, conducted as part of the Endoscopic Vision Challenge (http://endovis.grand-challenge.org) at the international conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) in 2015, was an effort to address this need. In this paper, we report the results of this comparative evaluation of polyp detection methods, as well as describe additional experiments to further explore differences between methods. We define performance metrics and provide evaluation databases that allow comparison of multiple methodologies. Results show that convolutional neural networks (CNNs) are the state of the art. Nevertheless it is also demonstrated that combining different methodologies can lead to an improved overall performance.

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Colonoscopy is widely recognised as the gold standard procedure for the early detection of colorectal cancer (CRC). Segmentation is valuable for two significant clinical applications, namely lesion detection and classification, providing means to improve accuracy and robustness. The manual segmentation of polyps in colonoscopy images is time-consuming. As a result, the use of deep learning (DL) for automation of polyp segmentation has become important. However, DL-based solutions can be vulnerable to overfitting and the resulting inability to generalise to images captured by different colonoscopes. Recent transformer-based architectures for semantic segmentation both achieve higher performance and generalise better than alternatives, however typically predict a segmentation map of $$\frac{h}{4}\times \frac{w}{4}$$ h 4 × w 4 spatial dimensions for a $$h\times w$$ h × w input image. To this end, we propose a new architecture for full-size segmentation which leverages the strengths of a transformer in extracting the most important features for segmentation in a primary branch, while compensating for its limitations in full-size prediction with a secondary fully convolutional branch. The resulting features from both branches are then fused for final prediction of a $$h\times w$$ h × w segmentation map. We demonstrate our method’s state-of-the-art performance with respect to the mDice, mIoU, mPrecision, and mRecall metrics, on both the Kvasir-SEG and CVC-ClinicDB dataset benchmarks. Additionally, we train the model on each of these datasets and evaluate on the other to demonstrate its superior generalisation performance.Code available: https://github.com/CVML-UCLan/FCBFormer.