Bonner, Samantha M. scite author profile

Bonner, Samantha M.

2Publications

23Citation Statements Received

69Citation Statements Given

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Affiliations

University of Michigan–Ann Arbor

Publications

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Sequence Variation in Promoter of Ica1 Gene, Which Encodes Protein Implicated in Type 1 Diabetes, Causes Transcription Factor Autoimmune Regulator (AIRE) to Increase Its Binding and Down-regulate Expression

Pietropaolo

Fan

et al. 2012

Journal of Biological Chemistry

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Background:Immunologic tolerance to tissue-restricted self-antigens primarily takes place in the thymus. Results: Sequence variation within the Ica1 promoter is associated with increased autoimmune regulator (AIRE) binding and transcription repression of ICA69 in medullary thymic epithelial cells. Conclusion: AIRE is a transcription repressor within the NOD mouse Ica1 promoter. Significance: A newly identified role for AIRE as a transcription repressor in medullary thymic epithelial cells.

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Sequence Variation in Promoter of Ica1 Gene, Which Encodes Protein Implicated in Type 1 Diabetes, Causes Transcription Factor Autoimmune Regulator (AIRE) to Increase Its Binding and Down-regulate Expression

M.¹,

Pietropaolo²,

Yang³

et al. 2012

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