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Introduction:Pseudomonas have now a days become a major cause of nosocomial and community acquired infections. They are widely distributed in the hospital environment which makes them difficult to eradicate. P.aeruginosa has become the leading cause of hospital acquired infection because of its recent trend to gain resistance to most of the drugs used against it causing a multidrug resistance. Therefore it is necessary to know the changing pattern so as to achieve a good therapy for pseudomonas infection. Therefore this study was conducted to determine the antimicrobial resistance pattern of P.aeruginosa with different parameters from the patients attending the tertiary level hospital in Chennai. Objective: The aim of the study was to enumerate the antimicrobial sensitivity pattern of Pseudomonas infection from various samples in a tertiary care hospital. Materials and Methods:The study was carried out in Microbiology department of a tertiary care hospital during the period of February 2016 to January 2017. A total of 93 non repetitive clinical isolates of P.aeruginosa were collected from different samples.Result: In the present study the males 51(54.8%) were more affected than females 42(45.2%).Age distribution showed more to be affected among adults of age 40 and above. Amikacin, Ciprofloxacin and Gentamicin shows 96.8% sensitivity. Among Cephalosporins highest resistance was observed among 1 st generation cefazolin (83.9%) followed by 2 nd generation Cefotaxime (17.2%) and Ceftazidime (23.7%) the least was seen among 4 th generation Cefepime which showed 6.5% resistance.All isolates were sensitive to Imipenem. Conclusion: Restriction of antibiotic usage must be formatted by each institution, to combat the emergence of multi drug resistant P. aeruginosa. Imipenem was the only anti-pseudomonal drug against which all isolates of P. aeruginosa were fully sensitive. We recommend a restricted and a more rational use of this drug in this hospital setting