The uncontrolled growth of cells in body often results in metastasis of overgrown tissue into other parts of the body. This medical condition is known as cancer. Angiogenesis, formation of new blood vessels from the preexisting ones, plays an immense role in supporting development and progression of cancer by providing oxygen and nutrients to these abnormally dividing cells. Chorioallantoic membrane (CAM) of chick embryos is a wellknown model system to study angiogenesis and for identification of angiogenic and anti-angiogenic molecules. Recently, Ranitidine, a commonly used antacid, has been banned in many countries due to its potential carcinogenic activity. Nitrosodimethylamine is thought to be the main contaminant and reason for this activity of Ranitidine. To our knowledge, this is the first report that evaluated the angiogenic potential of Ranitidine using chick embryo CAM model. Our preliminary observations demonstrate significant angiogenic activity of Ranitidine which may impart carcinogenic potential to it

Overuse of insecticides, without analyzing their harmful effects, can cause serious environmental issues. Coragen is a commonly used insecticide due to its broad range activity. In spite of enormous use, there are hardly any reports on the effects of coragen on non-target aquatic species and thus the environmental risk of coragen to aquatic ecosystem is underestimated. The present study was carried out to evaluate the potential risk of coragen on the water bodies and the life therein using hy dra, a fresh water simple diploblastic invertebrate, as the model system. Coragen was found to reduce the life expectancy of hydra along with the reduced ability to regenerate at various tried doses. The present study thus suggests precocious use of coragen due to its harmful effects on aquatic animals at v ery low concentrations also. The continued overuse of coragen may disturb the aquatic ecosystems at a large scale in long run.