Use of unauthorized synthetic drugs is a serious, forensic, regulatory and public health issue. In this scenario, consumption of drug-impregnated blotters is very frequent. For decades, blotters have been generally impregnated with the potent hallucinogen known as lysergic acid diethylamide (LSD); however, since 2013 blotter stamps with N-2 methoxybenzyl-substituted phenylethylamine hallucinogen designated as “NBOMes” have been seized in Chile. To address this issue with readily accessible laboratory equipment, we have developed and validated a new HPTLC method for the identification and quantitation of 25-C-NBOMe in seized blotters and its confirmation by GC–MS. The proposed method was validated according to SWGTOX recommendations and is suitable for routine analysis of seized blotters containing 25-C-NBOMe. With the validated method, we analyzed 15 real samples, in all cases finding 25-C-NBOMe in a wide dosage range (701.0–1943.5 µg per blotter). In this situation, we can assume that NBOMes are replacing LSD as the main hallucinogenic drug consumed in blotters in Chile.

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One of the most common illness in Chilean population are related with stress and anxiety, in that context Benzodiazepines are one of the most used medications in order to treat this symptoms. In this group one of the most consumed is Clonazepam, however the use of this Benzodiazepine also has secondary effects such as drowsiness, dependence and addiction. In this scenario is very important develop analytical technics in order to analyze the content Clonazepam in dosage forms and in biological fluids, such as urine, blood and oral fluid. Saliva or strictly referred to as oral fluid has recently gained a special interest due to its many advantages such as simple collection, due to is a non-invasive method, and the results of the analysis reflects recent consumption of this compound. Due to all this facts, and in order to satisfy the legal requirements, a novel, rapid and reliable methodology for the determination of Clonazepam in oral fluid is implemented using HPLC-UV-DAD liquid chromatography, and SPE extraction. This method appears to be suitable for Clonazepam analysis in oral fluid with accurate and consistent results.