With the fusion of information communication technology (ICT) in higher institutions of learning, new teaching and learning practices have developed—often called blended learning—allowing students and teachers to interact with information and each other more independently. This study, therefore, analyses the strengths, weaknesses, opportunities and threats (SWOT) of blended learning in the Public Universities of Uganda, in a case study of Muni University. Descriptive survey design was employed in the research. The target sample of the survey was 25 lecturers and 189 students selected using a stratified random sampling technique from the three faculties. A questionnaire was employed in this study and the data collected were analyzed using SPSS Version 25. The findings of the study identified accessibility, positive attitude, and knowledge and skills as the major motivators for blended learning. The strengths of blended learning found included serving many students in a short time, university readiness, connected both in and out of class, basic IT skills and top management commitment. The weaknesses included low bandwidth and unstable internet, lack of a plagiarism tool, insufficient numbers of computers and dependent on internet connectivity. Opportunities cited were competency-based systems that made it easier to manage individual progress in line with university expansion plans, an accessible way of learning regardless of location and available external support. The threats included unreliable power supply, unreliable internet connection, exchanges of username and passwords by students, internet shorthand used in student assignments. Based on these results, the study provides a baseline to help government and public universities that would like to implement or newly incorporate blended learning to identify strengths, weaknesses, opportunities and threats associated with the blended learning approach. The survey urges that plagiarism plugins for Moodle and BigBlue Button should be added, steady power supply should be provided, internet accessibility should be improved, blended learning training and workshops need to be improved and finally, policies, rules and standards pertaining to blended learning should be enacted.