The aim of this research was to determine the incidence, risk factors and perinatal outcome of the macrosomic infants (birth weight > or = 4000 g). The retrospective research was performed using a case-control study conducted at Mostar Clinical Hospital. Total of 379 women gave singleton term births to macrosomic newborn in the period from January 1st, 2004 to December 31st, 2005 (observed group). Another 379 singleton normal birthweight term newborns (birth weight < 4000 g, but not small for gestational age), of the same maternal parity and age, who were delivered in the same period, formed the control group. The incidence of macrosomic births was 13, 1%. In the study group, significantly higher number of cases of postdatism (> 42 weeks of gestation) (P<0,001), maternal obesity (prepregnancy BMI> 26 kg/m2) (P<0,001), gestational diabetes mellitus (P=0,033), hypertension (P=0,025) and male infant (P<0,001) were observed. Cesarean delivery (P<0,001), intrapartal complications (cephalopelvic disproportion P<0.001, perineal trauma P=0,042) and newborn birth trauma (clavicular fracture P=0,038, brachial palsy P=0,021) occurred significantly more often in the macrosomic group. There was only one fetal death in the macrosomic group. In the control group there were no cases of perinatal deaths. To conclude, it is important to emphasize the significance of proper diagnosis of fetal macrosomia and management of macrosomic birth, since we have seen a growing number of macrosomic births during the last decades, and have faced a problem of increased risks of adverse perinatal outcome.

Introduction: Early sexual activity and multiple sex partners are leading risk factors for the development of sexually transmitted diseases and cervical cancer. Raising the level of knowledge about measures to protect reproductive health among young people can lead to significant reduction of same. Aim: Aim of the study is to determine sexual activity, knowledge and views on measures to protect reproductive health among female students on the University of Novi Sad. Material and methods: The survey was conducted among 269 female students, on Faculty of Philosophy, Faculty of Agriculture and Faculty of Medicine, University of Novi Sad (age 19-24 years), from December 2018. to February 2019. An anonymous questionnaire was used as the instrument for the research. Statistical analysis was carried out in SPSS Statistics 20. Results: Early sexual activity, before 18 years had 33.7% of respondents (average age 16.44). A number of 32% of students had one, and 13.4% had 4 sexual partners or more. Condom use 62.2% of students, but 8% of women don't use any protection. One-third of students knows that HPV infection can cause cervical cancer, 60.6% didn't even hear for a vaccine against it. There is a statistically significant difference in knowledge about reproductive health in terms of contraceptive methods between medical female students and female students on other faculties, as well. Conclusion: There is a significant percentage of female students who had early sexual activity and low knowledge about reproductive health. This points to the need for more intense sex education in order to raise the level of knowledge about measures to protect reproductive health.